- Title
- There is no association between the Omega-3 Index and depressive symptoms in patients with heart disease who are low fish consumers
- Creator
- Cai, Shaoxin; Coates, Alison M.; Buckley, Jonathan D.; Berry, Narelle M.; Burres, Lisa; Beltrame, John; Howe, Peter R. C.; Schrader, Geoffrey
- Relation
- Heart Lung and Circulation Vol. 26, Issue 3, p. 276-284
- Publisher Link
- http://dx.doi.org/10.1016/j.hlc.2016.07.003
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2017
- Description
- Background: Long chain Omega-3 polyunsaturated fatty acids (LCn3PUFAs) may improve cardiovascular health and depression. This study investigated the relationships between erythrocyte membrane LCn3PUFA status, depression and angina symptoms in patients with heart disease. Methods: We recruited 91 patients (65 males and 26 females, mean age 59.2 ± 10.3 years) with heart disease and depressive symptoms (Center for Epidemiological Studies Depression Scale, CES-D ≥ 16) and low fish/fish oil intakes. The Omega-3 Index (EPA+DHA) of erythrocyte membranes (as a percentage of total fatty acids) was assessed by gas chromatography. Depression status was measured by both self-report and clinician-report scales; CES-D and the Hamilton depression scale (HAM-D). Angina symptoms were measured using the Seattle Angina Questionnaire and the Canadian Cardiovascular Society Classification for Angina Pectoris. Results: The mean Omega-3 Index was 4.8 ± 1.0% (±SD). Depression scores measured by CES-D and HAM-D were 29.2 ± 8.8 (moderate to severe) and 11.0 ± 5.7 (mild) (arbitrary units) respectively reflecting a different perception of depressive symptoms between patients and clinicians. Angina status was inversely associated with depression scores (r > -0.26, P < 0.03). There were no significant relationships between individual LCn3PUFA or the Omega-3 Index and either the depression scores or the angina symptoms. Conclusion: Worse angina status was associated with worse depression, but the Omega-3 Index was not associated with symptoms of depression or angina in patients with heart disease.
- Subject
- Omega-3 Index; depression; heart disease
- Identifier
- http://hdl.handle.net/1959.13/1391597
- Identifier
- uon:33258
- Identifier
- ISSN:1443-9506
- Language
- eng
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